Whether or not we think of it that way, caffeine is a drug. In fact, it’s the most commonly consumed drug in the United States. Most estimates suggest around 90 percent of Americans consume caffeine, in some form, every day. We’re no exception at the Ministry of Hemp. Actually, one survey suggested that journalists drink more coffee than any other profession, followed by police and teachers.

So what does it mean to mix CBD with this commonplace drug? Anecdotally speaking, some people swear by the benefits of adding CBD to your coffee. According to them, adding some CBD to your morning cup can reduce the jitters associated with caffeine, while also conferring CBD’s other benefits like stress relief and relief from inflammation.

However, a core goal of Ministry of Hemp is to share scientific knowledge with our readers. That’s why we decided to take a closer look at what current research suggests about CBD and caffeine.

Table of Contents

• What does science say about caffeine and CBD?
• What do CBD consumers say about combining CBD and caffeine?
• Final thoughts: Should I mix CBD and caffeine?

The science behind mixing CBD and caffeine

Just like so many aspects of our favorite plant, there’s not a lot of research looking directly at the effects of combining CBD and caffeine. 

Many research studies actually ask their subjects to abstain from alcohol and caffeine during most of their duration, meaning that a number of existing studies of CBD deliberately exclude the influence of caffeine. It’s also important to remember that clinical studies of CBD often use much higher doses than the average CBD consumer takes at home. That’s true for all kinds of research into cannabinoids, not just CBD & caffeine. 

Science doesn’t suggest “clear advantages to combining CBD and caffeine together.”

Source: Project CBD

That said, there have been a few studies that looked at the interaction between THC, caffeine and CBD, especially in relation to short-term memory. Project CBD summarized some of the existing research in an article published in May 2018. While THC is infamous for interfering with short-term memory, CBD may reduce these effects. But caffeine might actually interfere or even enhance the short-term memory loss caused by THC. 

Adrian Devitt-Lee, chief science writer for Project CBD, noted that it is unlikely that the combination of caffeine with cannabinoids could be “seriously problematic” for consumers. However, he added, “as of now, there aren’t clear advantages to combining or marketing CBD and caffeine together.”

It’s intuitively easy to imagine CBD’s relaxing effects could moderate caffeine’s stimulating effects. The reality of neurological chemistry is far more complex and harder to summarize. 

What do CBD consumers say about mixing the two?

The Ministry of Hemp podcast recently hosted Alwan Mortada, the founder of Ott Coffee. This innovative company adds CBD directly to the coffee beans during the roasting process. 

Mortada believes that adding CBD to coffee takes away some of the jitters and nervousness caused by caffeine consumption. He said it helps him maintain his energy while staying focused.

“It definitely helps me a lot with my ADHD, especially if I drink regular coffee as a [software] developer,” said Mortada during the show. 

Adding CBD to coffee “is pretty much one of our favorite things to do.”

Source: Redditor “Leafwize” on the CBD subreddit

There is limited research showing that while caffeine can increase the impulsivity associated with ADHD, CBD might moderate that impulsivity. The effects of this combination likely vary depending on the region of the brain being studied. That means it’s possible that there is some scientific basis for what Mortada described. Also notable: L-Theanine, an amino acid found in tea leaves, can also reduce caffeine jitters.

We also looked at the CBD subreddit on reddit.com. We often use this site to “take the pulse” of everyday CBD consumers. Numerous posters reported enjoying the combination of CBD and coffee. A few said they did not enjoy the effects of combining the two.

Redditor ‘Leafwize’ wrote that adding CBD directly to a morning cup “is pretty much one of our favorite things to do.” However, they and other redditors pointed out that the acidic nature of coffee likely causes chemical changes to the CBD.

Some redditors recommended enjoying CBD and caffeine together, but consuming them separately. For example, you might take a dropper of CBD oil before you begin drinking coffee, or even smoke a hemp flower joint as you enjoy your brew.

Should you mix CBD and caffeine?

As we so often find ourselves saying, we won’t really know the truth about CBD and caffeine until there’s more research looking directly at this topic. Since the legalization of hemp at the end of 2018, research of all kinds is blossoming so we may see a closer study of this topic in the near future.

In the meantime, it’s clear that CBD is overall very safe, perhaps even less likely to cause harm than overconsumption of caffeine. It’s also true that everyone’s personal biochemistry is different, especially when it comes to how you react to cannabinoids. 

With that in mind, we can only recommend that curious readers experiment for themselves and see how they feel when they combine caffeine and CBD. Let us know what you discover.

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Scientific advancements have helped us to find working treatments for countless debilitating conditions. However, there are some illnesses that continue to prove notorious and mysterious, with no known causes or cures. Research into the endocannabinoid system (ECS), a network in the body influenced by plant-derived cannabinoids, has provided medical experts with a fresh perspective on ailments such as fibromyalgia, irritable bowel syndrome (IBS) and migraines.

Dr Ethan Russo, a professional neurologist and cannabis researcher, first published the concept of a spectrum disorder in 2004. He first began working on the idea of dysregulation in the ECS in 2001. Both doctors and patients have noticed that cannabis and CBD oil seem to benefit people with these conditions. Russo has proposed that the effectiveness of cannabinoid medicine in the trio of aforementioned conditions can be explained by Clinical Endocannabinoid Deficiency (CECD).

INTRODUCING CLINICAL ENDOCANNABINOID DEFICIENCY

For the ECS to function efficiently, the body must produce endocannabinoids (naturally occurring, cannabis-like chemicals) such as anandamide (AEA) and 2-Arachidonoylglycerol (2-AG).

However, studies have found that some people have lower endocannabinoid levels than others, which brings about health complications. There is an increasing body of clinical research which shows anxiety to be associated with reduced anandamide levels, and major depression to be linked with reduced 2-AG levels. When the body is unable to produce endocannabinoids in the concentrations required, chemical imbalances occur, which leads to illness.

Cannabinoid receptors interact with both endocannabinoids and cannabinoids, with the plant-derived compounds able to mimic endocannabinoids or otherwise influence them for ECS regulation. Therefore, it is logical that a cannabinoid treatment could effectively remedy CECD.

Russo’s latest significant update on his CECD research came in 2016, with a paper that continued to build on the concept, incorporating available clinical evidence. This followed an earlier 2008 release.

FIBROMYALGIA AND CLINICAL ENDOCANNABINOID DEFICIENCY

Medical researchers have been unable to come up with a definite cause for fibromyalgia. Patients suffer from an array of debilitating symptoms that have a significant effect on quality of life. These symptoms include chronic deep muscle and tender point pain, impaired cognitive function (or “fibro fog”), headaches, sleeping difficulties and restless leg syndrome. According to the Anxiety and Depression Association of America, 20 percent of fibromyalgia patients experience one of or both of these mental health disorders. Typically, this is a result of the pain and fatigue caused by the condition. In 2011, a study found that CBD could reduce anxiety beyond placebo levels, with patients given a 600mg dose administered via CBD capsules.

Moreover, several symptoms of fibromyalgia are indicative of ECS dysregulation — for instance, inflammatory conditions occur due to problems with immune system response, which is modulated by the ECS and specifically the CB2 receptor. Studies have also found that serotonin levels are affected in fibromyalgia patients, which may be noteworthy considering CBD is an agonist of the 5-HT1A receptor.

MIGRAINES AND CLINICAL ENDOCANNABINOID DEFICIENCY

Around 39 million Americans are affected by migraines, according to the Migraine Research Foundation. Migraines can cause dizziness, nausea, numbness or tingling in the face and other unpleasant symptoms. Research has shown that migraine sufferers have “statistically significant” differences in anandamide levels in cerebrospinal fluid, which is found in the brain and spinal cord.

Russo found that endocannabinoid system changes could help to alleviate migraines in his 2004 research. The main finding was that anandamide, a key neurotransmitter in the ECS, heightens the effectiveness of the 5-HT1A receptor while inhibiting the 5-HT2A receptor. This could help with treating acute migraines and as a preventative treatment. Furthermore, the results showed that several cannabinoids exhibited anti-inflammatory properties and dopamine-blocking effects.

The light and sound sensitivity that results from migraines may be due to an overactive nervous system. The ECS is renowned for regulating such imbalances (Russo, 2016). Some have suggested that the root cause of migraines can be traced back to the trigeminovascular system, which brings blood to the brain. Studies have shown that endocannabinoids can influence this system. Migraines and cluster headaches may be best managed with a treatment that is an agonist of the CB1 receptor.

In the case of migraines, one study found that while a CBD and THC treatment was not necessarily more effective than existing anti-migraine treatments, the side effects were significantly reduced.

Fascinatingly, cannabis was a common treatment for migraines in Europe and North America from the mid-1800s until the 1940s, a time when the herb was being prohibited around the globe.

NEXT STEPS IN CANNABINOID RESEARCH

As governments all over the world look into the benefits of medical cannabis, the number of high-quality studies being carried out in clinical settings is sure to increase.

With time, we should get an in-depth look at the potential of cannabinoids as a treatment for fibromyalgia, migraines and other illnesses. As our understanding of the ECS deepens, we may learn more about the wide-scale implications of dysfunction in the system.

Furthermore, more research needs to be done on the possible interactions cannabinoids have with receptors outside of the ECS and the effects this may have on the body.

CLINICAL ENDOCANNABINOID DEFICIENCY SHOWS HOW MUCH WE HAVE LEFT TO LEARN

It’s essential to bear in mind that the work of Dr Russo and others on CECD is at the forefront of cannabis science, and we still have plenty to learn about the endocannabinoid system, the effects of its dysregulation, and the genuine potential of cannabinoid-based medicines for treating notoriously complicated conditions such as fibromyalgia.

However, the theory has certainly fleshed out since 2004. There are studies that suggest medical cannabis and CBD can have a therapeutic effect for certain conditions. But in his 2016 paper, Russo noted that contradictions in CECD research were common. He reported that excessive levels of endocannabinoids could also be damaging for health, potentially leading to obesity and hepatic fibrosis.

Regulation of the endocannabinoid system is probably not be as simple as taking a dose of CBD or THC. There are dozens of cannabinoids in hemp and cannabis. Research indicates that whole-plant tinctures can be preferable to isolates of just one chemical. Given that endocannabinoid imbalances differ from patient to patient, the ideal medication for these imbalances may vary too. Perhaps someday, these treatments may be more be tailored to fit a person’s exact illness.

It’s clear we still have a lot more to learn about the endocannabinoid system before we can fully understand how it contributes to our health and well-being.

DISCOVER THE TOP CBD BRANDS

The market is getting saturated with many different CBD brands. We’ve compared the top brands to help you with your decision. Check it out.

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Cannabidiol (CBD) is a chemical compound that is present in hemp, a close relative of marijuana. It is nonpsychoactive—meaning, it doesn’t make people feel stoned. CBD is also known to have various medical benefits that can help relieve patients from pain, inflammation, anxiety, lethargy, and other conditions. When taken, CBD allows a person to feel relaxed without the intoxication.

WHAT MAKES CBD DIFFERENT FROM THC AND OTHER CANNABINOIDS?

CBD is notably different from other cannabinoids, or chemicals which are found in hemp and cannabis. While all other cannabinoids interact with two significant receptors in the nervous system, CB1 and CB2, CBD has very little effect on both of them. CB1 receptors are found in different parts of the brain, including those concerned with emotion, sensory perception, memory, and cognition. CBD does not induce a mind-altering state.

Tetrahydrocannabinol (THC), on the other hand, is another story. It is the chemical responsible for majority of cannabis’s psychological effects, sending you on a cerebral adventure. It is found mainly in the resin secreted by the glands of the marijuana plant. THC attaches itself to both CB1 and CB2 receptors. This activates them and affects a person’s thinking, perception, memory, pleasure, and concentration, making the person feel high.

CBD may also moderate the effects of THC. While some people report anxiety from consuming marijuana, strains which are high in CBD tend to cause less of these effects. CBD itself may be beneficial in the treatment of anxiety.

POSSIBLE NEUROLOGICAL EFFECTS OF CBD

CBD is known to have several medicinal properties, but because the field of marijuana studies is fairly young, more research is needed to explore the properties of marijuana’s compounds. Here are some of the possible medical benefits of CBD. More research is needed to determine whether CBD can effectively be used to treat all these conditions.

• Neuroprotective Effects

CBD could be useful when treating neurological diseases because it protects neurons from degeneration. In a study about Alzheimer’s, CBD was seen to hinder and the development of Alzheimer’s symptoms.

• Analgesic Effects

CBD has proven itself useful in suppressing pain. It is able to inhibit neuronal transmission without causing analgesic tolerance. Because of this, researchers suggest that CBD and other nonpsychoactive components can be used as a foundation to the treatment of chronic pain.

• Antitumor Effects

Studies have shown that very high doses of CBD no toxic effects in humans and that it might be used to inhibit the growth of cancer cells due to its antitumor properties. This could even help treat leukemia and similar diseases.

• Antianxiety Effects

CBD has been shown to reduce anxiety in patients. Researchers have also suggested that it can be used on patients with a variety of related conditions including Post Traumatic Stress Disorder.

In a 2011 study, a test was administered to 24 patients with social anxiety disorder. 1.5 hours before the test, the patients were given CBD or placebo. It was found out that the anxiety, cognitive impairment, and discomfort in patients who were pretreated with CBD had significantly reduced, compared to those in the placebo group.

HOW CBD WORKS IN THE BRAIN

CBD produces effects through various molecular pathways. Although CBD does not really bind with two of the cannabinoid receptors, CB1 and CB2, it acts through several different receptor-independent channels. CBD enhances and inhibits the binding action of certain protein-coupled receptors.

Listed below are some of the receptor systems and their relationship with CBD.

• Serotonin System

CBD targets a specific serotonin receptor, the serotonin 1A receptor. Its affinity with this receptor is associated with a lot of CBD’s therapeutic properties.

Take note that serotonin receptors regulate the release of hormones like cortisol, which is responsible for metabolism and reactions to stress, and oxytocin, which affects social behavior. Serotonin receptors also affect a person’s mood, cognition, and appetite.

Enhancing the activation of serotonin 1A receptors supports the theory of how CBD impedes certain problems and disorders such as neuropathic pain, anxiety, depression, schizophrenia, and nausea from chemotherapy.

• • Vanilloid Receptors

CBD binds to TRPV1 receptors, which are also called vanilloid receptors, to achieve a therapeutic effect. As an ion channel, TRPV1 plays a role in thermoregulation (temperature regulation), inflammation, and the perception of pain.

• • Orphan Receptors

GPR55 is called the orphan receptor because researchers are still not sure if it belongs to a larger receptor family tree. It is involved in the process of modulating blood pressure, bone reabsorption, and bone density.

When it is overactive, GPR55 may cause osteoporosis. GPR55 also contributes to the multiplication and migration of cancer cells. CBD blocks GPR55 signaling. This could affect the likelihood of cancer cells proliferating under the right conditions.

• • Nuclear Receptors

Peroxisome proliferator activated receptors (PPARs), also known as “nuclear receptors,” are activated by CBDs to produce an anticancer effect. They are found on the surface of the cell’s nucleus. When activating a receptor known as PPAR-gamma, an antiproliferative effect begins. Its activation also causes tumors to regress in lung cancer cell lines.

CBD AS AN ANANDAMIDE REUPTAKE INHIBITOR

According to a study, CBD in the brain inhibits anandamide reuptake and breakdown, which increases endocannabinoid levels in the brain’s synapses. Anandamide is an extremely powerful, cannabis-like chemical in the brain. This, in turn, has neuroprotective effects against seizures and other problems.

Since it is a plant compound, CBD has to pass through the cell membrane to get inside a human cell and bind with a nuclear receptor. It does this by attaching itself with a fatty acid binding protein (FABP), which takes it into the cell’s interior. The same intracellular molecules also transport THC and the brain’s cannabis-like molecules, the endocannabinoids anandamide and 2AG, to different parts inside the cell.

CBD has a strong attraction to three kinds of FABPs. This causes CBD to compete with endocannabinoids. Once endocannabinoids are inside the cell, anandamide is broken down by fatty acid amide hydrolase, a metabolic enzyme. CBD interferes with endocannabinoids’ process by reducing anandamide’s access to transport FABP and delaying it from entering the cell.

THERAPEUTIC EFFECTS OF CBD IN THE BRAIN

CBD has therapeutic properties that can aid individuals facing both physically and psychologically related problems.

• • Anxiety, Stress, and Depression

While THC can amplify the anxiety in some people, a study done by Neurotherapeutics suggests that CBD can help lessen the anxiety felt by people with particular anxiety disorder. The neurological effects of CBD could lead to it being used as a supplement to existing treatments like pharmaceutical drugs.

• • Epilepsy

A study posted in Epilepsia suggested that CBD is able to treat epilepsy and neuropsychiatric disorders. Since CBD has antiseizure properties, it has a low risk of adverse side effects on people who already have epilepsy. Because of this, there are more and more studies being conducted with the focus to treat many of the disorders linked to epilepsy, such as neuronal injury, neurodegeneration, and psychiatric diseases.

• • Sleep Quality

Since CBD can help reduce anxiety, this, in turn, can help out with sleep difficulties. It may increase the overall amount spent sleeping by subduing chronic pain and insomnia. At a small dosage, CBD induces wakefulness and reduces daytime sleepiness, but heavy doses taken a few hours before bedtime have a balancing effect that often leads to a good night’s sleep.

CBD’s IMMENSE POTENTIAL

While most of the studies have put their focus on understanding THC, cannabidiol has been consistently showing great potential with regard to its medical uses. It is important to understand all the properties of cannabis and hemp so that people can use it to help benefit the human body.

As they understand this chemical more, scientists may find newer ways to improve human health and healing, without having the fear of the stigma that comes with cannabis.

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