hemp research Archives - Ministry of Hemp America's leading advocate for hemp Tue, 16 May 2023 06:58:23 +0000 en-US hourly 1 https://wordpress.org/?v=6.2.2 https://ministryofhemp.com/wp-content/uploads/2022/12/Icon.png hemp research Archives - Ministry of Hemp 32 32 Hemp Supercapacitors Bring Green Tech To A Higher Level https://ministryofhemp.com/hemp-supercapacitors/ https://ministryofhemp.com/hemp-supercapacitors/#comments Mon, 15 May 2023 19:04:04 +0000 http://ministryofhemp.com/?p=54739 Outperforming standard supercapacitors up to 200 percent, hemp-based supercapacitors could be the future of green technology. Hemp could be a key part of making our energy needs more sustainable.

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Outperforming standard supercapacitors up to 200 percent, hemp-based supercapacitors could be the future of green technology.

At the Ministry of Hemp, we’re a little biased about our favorite plant in the world: hemp. But it seems like everyday we find newer and better ways that it can be used.

One innovation we recently discovered? Scientists discovered how to use hemp fiber in supercapacitor electrodes. A supercapacitor is the lesser-known alternative to traditional electrical energy storage. Right now, a supercapacitor is the second best option for storing power, after batteries. However, more research could change that.

An illustration of a seemingly infinite number of batteries, with a small cluster rising above the others. A green colored battery is higher than the rest.Supercapacitors could be the future of energy density and energy storage, hemp supercapacitors could prove even more efficient than other materials.

Below we’ll introduce you to hemp supercapacitors and how hemp could play a part in our energy future.

WHAT’S A SUPERCAPACITY, ANYWAYS?

The most famous form of energy storage is the battery, an object that contains two opposing electrical terminals separated by electrolytes. When you turn on the power, a chemical reaction occurs between the electrolytes and electrodes, producing electric energy for your device.

Since batteries rely on electrolyes, and electrolytes wear out, all batteries need to be replaced. In addition, batteries take a very long time to fully charge. Today, we use batteries everywhere; in our phones, laptops, and more recently, our cars.

Capacitors work very differently from the traditional battery. In short, a normal capacitor is comprised of two metal plates and an insulating material between the plates called a dielectric. In a capacitor, positive & negative build up on the plates. Rather than electrolytes, capacitors store electrical energy within the plates.

Supercapacitors on the other hand, are different for two ways. Their plates have a “bigger” surface area and the distance between the plates is much shorter. Supercapacitors are usually coated in a porous substance such as activated charcoal. These coatings are called the “supercapacitor electrodes.”

The electrodes serve as more storage on the plates, giving them more surface area to store electricity. Think of normal non-coated capacitors as mops; which can only absorb so much water, and supercapacitors as sponges, soaking up much more water than its surface area. The website Explain That Stuff published a great explanation of supercapacitors in August.

Unlike batteries, supercapacitors charge almost instantaneously and last much longer than batteries. Their biggest drawback, preventing them from being the popular choice, is the amount of energy that is able to be stored within them. Right now, supercapacitors only store a fraction of the power of a traditional battery, but scientists are working hard to find a way around this problem.

THE MIGHTY HEMP-SUPERCAPACITOR

Today’s supercapacitors commonly use graphene, a carbon nanomaterial to create electrodes. But making graphene with hemp based carbon nanosheets costs up to $2000 per gram.

In 2013, Researchers at the University of Alberta National Institute for Nanotechnology found a more economical material in hemp. These scientists discovered how to process raw hurds (the plant’s woody core) into activated carbons through hydrothermal processing and chemical activation. The final product is one that’s able to soak up more electricity, providing better energy capacity.

The solution produces not only a cheaper material — $5000 per ton — but one that performs up to four times better than graphene. Better yet, the solution uses the hemp stems, the part that is often left unused during other forms of hemp processing. With this, the entire plant is used, and no part is left to waste!

A handful of dried hemp cores, looking a lot like wood chips. Hempcrete building material is one common use for hemp hurds or shivs, the woody core of the plant. Someday, they could be used in hemp supercapacitors too. Hempcrete building material is one common use for hemp hurds or shivs, the woody core of the plant. Someday, hurds could be used in hemp supercapacitors too.

If this solution can be easily reproduced, it would affect far more than just the electronics industries. Supercapacitors represent a fundamental shift in energy storage.

Imagine if every battery powered object used hemp powered instead! It would mean that hemp would be undeniable in its utilitarian value. Remaining anti-hemp governments would be hard-pressed to keep the plant banned from commercial use.

LEGAL HEMP MEANS MORE HEMP RESEARCH

With the passing of the Farm Bill — making industrial hemp a lawful agricultural commodity in the United States — hemp research is ready to take a big leap. Someday, we could be driving hemp-powered cars and using phones that are powered by hemp!

Not only will consumer products change with legal hemp, but if hemp supercapacitors are adapted to a larger scale, we might see a shift in the infrastructure of the entire country.

The possibilities for this greener, cleaner, and sustainable crop seem limitless! With legal hemp, countless industries stand to benefit.

 

 

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CBD For Older Dogs: Discussing New ‘Pain’ Study On Dogs & CBD https://ministryofhemp.com/cbd-for-older-dogs-podcast/ https://ministryofhemp.com/cbd-for-older-dogs-podcast/#respond Sun, 07 Aug 2022 22:28:00 +0000 http://ministryofhemp.com/?p=62378 Dr. Matthew Halpert joins the 50th episode of the Ministry of Hemp podcast to discuss a recent study he coauthoried on treating older dogs with CBD.

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There’s growing evidence that CBD can help dogs, and today we talk to an expert.

First in this episode of the Ministry of Hemp podcast, Matt starts out talking about CBD scams and false claims to watch out for, based on a recent article by our editor Kit O’Connell.

Today, our host Matt talks with Dr. Matthew Halpert about a new study he coauthored in the scientific journal PAIN. This research looked at whether CBD can help aging dogs with osteoarthritis. One of our Top CBD Brands, Medterra, partnered with the researchers on this study.

Their conversation touches on some new and exciting evidence showing CBD’s ability to reduce inflammation, a new CBD delivery system that could change the way we take CBD, and the weird biological origins of bleach.

This is episode 50 of the Ministry of Hemp podcast! Thank you for listening, and sharing our podcast with your friends.

About Dr. Matthew Halpert

Equipped with a Ph.D. from the University of Alabama-Birmingham, Dr. Halpert is the Director of Research & Development at Medterra. He is currently responsible for all product-related R&D from performing pharmokinetic studies on efficacy to reviewing the latest peer-reviewed publications on CBD. Halpert also holds a faculty position at the Baylor College of Medicine where he studies both the efficacy and immunological processes, homeostatic regulation and cancer immunotherapy.

You’ve got hemp questions? We’ve got hemp answers!

Send us your hemp questions and you might hear them answered on one of our Hemp Q&A episodes. Send your written questions to us on Twitter, Facebook, matt@ministryofhemp.com, or call us and leave a message at 402-819-6417. Keep in mind, this phone number is for hemp questions only and any other inquiries for the Ministry of Hemp should be sent to info@ministryofhemp.com

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Photo: A composite image showing, on the left, Dr. Matthew Halpert, a young white man with short dark brown hair, smiling, wearing a formal shirt and jacket. To the right, an older brown-furred dog plays on the beach. Dr. Matthew Halpert coauthored a study which looked at whether CBD could help older dogs with arthritis.
Dr. Matthew Halpert coauthored a study which looked at whether CBD could help older dogs with arthritis.

CBD For Older Dogs: Complete episode transcript

Below you’ll find the complete transcript of episode 50 of the Ministry of Hemp podcast, “CBD for older dogs”:

Matt Baum:
I’m Matt Baum and this is the Ministry of Hemp podcast, brought to you by MinistryofHemp.com, America’s leading advocate for hemp and hemp education.

Matt Baum:
Today on the show, we are going to get into some science. It’s one of my favorite things to talk about because science is how we learn that things work and it looks like there is some real evidence finally coming out to show that CBD actually really does help with inflammation. My conversation on the show is going to be with Dr. Matthew Halpert. He is research faculty in the Department of Pathology and Immunology at Baylor and he just recently worked on a study looking at osteoarthritis in dogs and how CBD can help. But before we get into the science, we should talk a little pseudoscience and some very popular scams that are going on in the CBD world right now.

Beware CBD scams & frauds

Matt Baum:
As I’m sure you know, CBD oil has become an extremely popular fad in the past few years. There’s even consumer reports survey that says 40% of people in their 20s have tried CBD oil and up to 15% of people 65 or older have tried it. I’m sure you’ve talked to or read about people that say it’s helped with their aches or their anxiety, but there’s just as many people out there on the internet right now that’ll tell you it cures everything from cancer to Covid-19 and unfortunately because CBD is currently not regulated by the FDA, legally, they’re getting away with it.

Matt Baum:
Now, normally on this show and on MinistryofHemp.com, we like to highlight people that are creating CBD for the right reasons and doing it the right way. But I wanted to take a moment to highlight some of the people that are doing it the wrong way. The scammers out there that are looking to take advantage of you for money while they can, before the FDA moves in and starts regulating CBD.

Matt Baum:
The first and brightest warning flag you should look for are claims that it cures everything. If you find a product with a laundry list of different ailments saying that CBD cures it, makes it go away, chances are they’re lying. As we’ve said on this show and on our site, and I repeat over and over again, we’ve seen CBD useful in treating inflammation, pain, and anxiety. Now, that is not to say that we won’t learn other uses for CBD later, but for now, that is what we know that it does. Anyone claiming that it cures the common cold, cancer, your skin rash, your dog’s bad attitude … I suppose it could help if your dog has anxiety but it’s not going to make your dog stop biting you. But CBD is not going to cure disease and along those same lines, anyone that is boasting about CBD and immune boosting, is probably selling you snake oil. There is no evidence that CBD is boosting your immune system. That’s not even how your immune system works. And again, it’s a real quick and easy red flag to notice.

Matt Baum:
Another one that absolutely blows my mind, CBD infused products that you can’t take internally. I’m talking about CBD infused bracelets, CBD infused pillows, CBD infused mattresses. That is not how CBD works. If not taken internally, it is not doing you any benefit and I am not going to tell you to eat your pillow to get those benefits. There’s all kinds of great companies that are putting out fantastic CBD gummies, oils, tenures, vapes, all of which, you may notice, are taken internally. Anyone that is trying to sell you an external product that you wear or lay on or think about, chances are, they’re selling garbage and it’s not going to help you. It might be comfortable, but it’s not going to give you any of the benefits that you would get from a quality CBD product that is taken internally. We’ve got a fantastic article right now that has some more scams that are up. You can look over at MinistryofHemp.com and I’ll have a link to it in the show notes. I highly suggest you check it out.

Matt Baum:
I know this stuff sounds like common sense, but unfortunately while this was all unregulated, there are people making wild claims and selling garbage products that can make reputable companies look bad when someone tries some really cheap, Chinese imported CBD they got off Amazon that doesn’t even have any CBD in it. That can make a really bad impression. Go check out this article, educate yourselves and make an educated buying decision before you spend real money on CBD. So you know what it is, you know what’s in that bottle that you’re buying, and you know what it’s supposed to do.

Meet Dr. Matthew Halpert

Matt Baum:
My conversation on the show today is with Dr. Matthew Halpert. He is part of the research faculty in the Department of Pathology and Immunology at Baylor. Now, recently he worked on a study in conjunction with Medterra. Medterra is a CBD company that offers a whole line of different products, including animal products. This study was carried out on dogs to look at how CBD affects the inflammation levels in older dogs suffering from osteoarthritis, which is very prevalent. Here’s my conversation with Dr. Matthew Halpert.

Matt Baum:
Dr. Halpert, welcome to the Ministry of Hemp podcast. It’s nice to have you here.

Matthew Halpert:
Thank you.

Matt Baum:
We’re going to talk about the study that you worked on that came out of Baylor Medical School about animals with osteoarthritis pain. I had to practice that so I didn’t sound stupid when I said it. And how they reacted to CBD. I looked at this study and 99.9% of it was clear over my head. So we’re going to get the dumbed down third grade version, if you will.

Matthew Halpert:
Sure.

Matt Baum:
That’s what I brought you in for, basically.

Matthew Halpert:
Sure. No problem.

Matt Baum:
Before we get started, tell me about you. How does a guy like you, who specializes in immunology end up on a study like this?

Matthew Halpert:
Sure. First things first, let me throw out a bit of a disclaimer. When we get into the part about the dog study, it is important to know that all of the K-9 subjects were seen by highly qualified veterinarians at Sunset Animal Hospital and not at Baylor College of Medicine. We were not in a lab at Baylor experimenting on these animals. These were properly cared for previous patients of veterinarians at Sunset Clinic.

Matt Baum:
That’s good to know because when you start thinking animal lab, you go straight to horror story. Right?

Matthew Halpert:
Yeah. And Baylor doesn’t want to get in trouble. I did not actually touch a dog.

Matt Baum:
Totally get that.

Matthew Halpert:
I’m a PhD, not a vet. So just to be clear on that. I didn’t used to think about being clear on that until I got a little … I have to be very clear on that.

Matt Baum:
A talking to, if you will.

Matthew Halpert:
Yes.

Matt Baum:
I assure you, this is not a [inaudible 00:07:29], I promise you.

Matthew Halpert:
The paper did come out of Baylor and they were like, you need to be clear, we did not experiment on dogs. This was all done underneath the supervision of appropriate veterinarians and regulatory oversight.

Matt Baum:
Makes perfect sense.

Matthew Halpert:
To address your question, by trade I’m an immunologist and as you know, a couple years ago cannabis, cannabinoids, CBD, in particular, all really started surging forward with the passage of the 2018 Farm Bill. When it was de-scheduled and no longer in the same category as heroin or LSD, it became much easier for researchers to obtain it and to research with it. So my focus up to that point, or part of my studies had been in inflammation and the process of inflammation and what goes into that and of course, inflammation is a growing, almost pandemic, at this point. With our Western diet, we’re all sitting right now. The amount of time we sit actually causes inflammation.

Matthew Halpert:
Aging, aging by itself causes inflammation. So we’re just an inflamed people and it’s just getting worse and worse and worse until eventually you end up with some sort of chronic or severe disorder. An example would be osteoarthritis, which affects 35 million Americans a year and as best I can tell right now, one of the main causes is inflammation. Other than that, there’s a lot we don’t know.

Matt Baum:
Fair enough.

Matthew Halpert:
So, obviously it would be beneficial if we could reduce inflammation but you don’t want to go get a shot of steroids every week. That’s a pretty severe path. A lot of people do turn to basically overdosing themselves with NSAIDs like ibuprofen and Tylenol and asprin. The number one cause of liver transplant patient in this country is accidental overdose of acetaminophen-

Matt Baum:
It’s not alcohol.

Matthew Halpert:
Which is Tylenol.

Matt Baum:
It’s Tylenol.

Matthew Halpert:
It’s not. People have no idea how dangerous Tylenol is.

Matt Baum:
That is amazing. I had no clue.

Matthew Halpert:
They think it’s like candy and many people, including myself, have said, Tylenol was basically grandfathered in because it was so old. If it had to go through the FDA rigors of today, it would probably never be approved.

Matt Baum:
Really?

Matthew Halpert:
Yeah, it’s pretty damaging to your organs. For the people who-

Matt Baum:
I’m going to get rid of that then. Let’s get that out of my medicine cabinet.

Matthew Halpert:
Be careful with it. People don’t know but you can overdose yourself with that.

Understanding inflammation and arthritis

Matt Baum:
Real quick, on the subject of inflammation, as I understand it, inflammation is not necessarily arthritis but is a symptom of arthritis and it is the symptom that causes the pain? Is that correct?

Matthew Halpert:
Well, by definition, symptom comes after the cause.

Matt Baum:
Makes sense.

Matthew Halpert:
It’s probably more on the cause side. But it’s throughout. It goes both. Having inflammation does not mean you have arthritis nor does it mean you will get arthritis. It is just associated in people that have arthritis, yes. They definitively have excessive inflammation in their knee or their elbow or wherever the arthritic issue is. So other forms of chronic … a lot of GI disorders, Crohn’s, IBD, those are examples of excessive inflammation in our GI tract. Excessive inflammation in the lungs can lead to asthma or COPD or a number of bronchial issues. So just depends on where the inflammation is. To make it more relatable to the lay person, inflammation is not per se caused by anything external. It’s not caused, a bacteria or virus itself, or whatever you may encounter, does not inflame you. The inflammation is your body’s immune response against that.

Matt Baum:
To something else. Got it.

Matthew Halpert:
There’s a virus, we need to destroy it, inflammation. And in that case, you want that. But for a lot of people, it’s basically an immune response gone rogue and there’s inflammation to your own … Rheumatoid arthritis, you have an immune response against yourself. It’s an autoimmune disorder.

Matt Baum:
Right. Your body starts attacking yourself.

Matthew Halpert:
So you have all this inflammation which can be characterized by a number of things, including the accumulation and activation of different inflammatory cells. Neutrophils is a very popular one. They can rapidly get to, in this case, the synovial joint. Neutrophils actually secrete bleach. That is one of the things they use to kill bacteria. But in this case-

Matt Baum:
Chemical bleach? Strait up bleach? The same stuff you would add to your wash?

Matthew Halpert:
Well, where do you think they discovered the chemical form bleach from?

Matt Baum:
I did not know that.

Matthew Halpert:
Yep.

Matt Baum:
That’s news to me. All right.

Matthew Halpert:
Neutrophils release a lot of toxic agents, commonly referred to as reactive oxygen species, or ROSs. They’re just very toxic and they’re useful in acute situations but obviously damaging if they continue and persist because they will damage your own cartilage and anything else in the area. You also have inflammatory cytokines such as TNF Alpha is a very popular one. These, again, what they tell your body is danger, danger, danger.

Matt Baum:
Attack.

Matthew Halpert:
We need to attack and if you’ve got too much of that, especially at the wrong time, that’s when you say ow, I’m feeling pain. Maybe I should rub something on it or take some Tylenol or etc.

Matt Baum:
So this is where CBD comes in that you were studying.

Matthew Halpert:
Right. So it’s never going to be something I recommend to overdose yourself with NSAIDs. You always run a risk of the benefit not outweighing the damage.

Matt Baum:
And the NSAIDs being painkillers like Tylenol?

Matthew Halpert:
NSAIDs, non-steroidal antiinflammatory. Yes.

Matt Baum:
Non-steroidal antiinflammatory.

Matthew Halpert:
Common ones are acetaminophen or salicylic acid, which is Asprin, ibuprofen which is Advil. I mean, there are others but people just, “Oh, yeah, I’ll just take those.”

Matt Baum:
Well, they’re harmless. Right?

Matthew Halpert:
They’re harmless. Next thing you know you’ve damaged your organs, possibly beyond repair. It has its effects especially if you’re taking … and I fully admit, I used to not know this when I was an athlete back in my younger days, I was definitely overloading on Advil just to get through some pain.

Matt Baum:
Same here. I played hockey and I was a drummer so my hands got inflamed and hurt and I took Tylenol and when that stopped working, a doctor put me on hardcore painkillers, I got addicted to those, it was great. You don’t even know you’re a drug addict. You’re just walking around addicted.

Matthew Halpert:
This is nothing to even discuss about the opioid issue in this country.

The anti-inflammatory properties of CBD

Matt Baum:
And that’s the whole next level I could have gone. I was lucky. And then I found CBD and that’s helped quite a bit with the inflammation in my hands and pain.

Matthew Halpert:
Right. So as we move the needle forward and I’m working in the lab and studying inflammation and ways to potentially reduce it, let’s say safer, more efficiently, more economically, there was the surge in interest in CBD. Anecdotally, I’m sure you’ve read CBD cures everything.

Matt Baum:
Oh, of course.

Matthew Halpert:
Headaches-

Matt Baum:
It’s doing a great job on Covid right now, from what I understand.

Matthew Halpert:
Oh, sure. Cures that. If you end up dying, it’s okay. Take a little CBD. You’ll be fine.

Matt Baum:
You’ll be all right.

Matthew Halpert:
I did not really want to … I do not follow the anecdotal, obviously. I’m a scientist. That means very little to me. It can push us and skew us to what to look at and there happen to be a decent amount out there and some previous research. I’m not the first. There has been other research that shows that, oh, CBD actually does have some really interesting antiinflammatory properties. And initially this was mistakenly assumed that it was only through the endocannabinoid system. The CB1, CB2 receptors which I’m sure you’ve heard of.

Matt Baum:
We talk about them all the time.

Matthew Halpert:
And while there’s no doubt that CBD can interact with those receptors, I would venture to say in all likelihood, that is not even the main receptor CBD interacts with when you take it. It has now been shown to interact with a number of different receptors. Some really interesting. It stimulates through the serotonin receptor, which is your feel good receptor in the brain. That could be very interesting. And not to get too science-y but there has now been identified between six and 10 different inflammation related receptors that CBD actually interacts with.

Matt Baum:
That’s amazing news though. That’s great.

Matthew Halpert:
Mm-hmm (affirmative). Absolutely.

Matt Baum:
We started with CB1 and CB2 and the endocannabinoid system and everybody pushes that and we go, yeah it’s very cool but the news that no, there’s way more benefit to it than that. That’s even better. That’s fantastic news.

Matthew Halpert:
Exactly. CBD, I mentioned before, neutrophils, well CBD can bind directly to neutrophils and reduce their activity. Great. That’s what you want. You want to shut that down. Can it reduce TNF Alpha? Yes. If you go back and look at the paper that you were referring to before that I just published in [inaudible 00:17:25], you can see that.

Matt Baum:
Real quick. TNF Alpha?

Matthew Halpert:
Tumor Necrosis Factor Alpha. It’s a very, very commonly … I mean, you can see commercials, they talk about it in commercials for Humira, for example.

Matt Baum:
Oh, sure.

Matthew Halpert:
TNF Alpha is an inflammatory cytokine elevated in a number of different conditions and it’s sort of become one of the hallmark proxies of, “You may have an inflammatory condition somewhere if we’re identifying increases in that in circulation.”

Matt Baum:
Gotcha. I thought you were saying TN Alfalfa. And I was like, that sounds delicious.

Matthew Halpert:
TNF Alpha. And in fact, in rheumatoid arthritis, which is slightly different, that’s one of the therapies they employ. Is simply blocking that molecule can bring patients a lot of improvement by blocking that. That’s why I mention it, why I looked at it, and why it ended up being in the publication. Not that I’m the first to discover that CBD can reduce that but it’s important to, of course, always verify previous research and then build off it.

Matt Baum:
Right. Obviously.

Matthew Halpert:
So we did that in several different inflammatory models and again, successfully saw, yeah, CBD does in fact do that.

Studying arthritis & CBD in older dogs

Matt Baum:
Let me ask you, you can do this, we’re seeing the science and it’s working, and it’s amazing and we can talk to people and say, “How do you feel?” And you do, “What’s your pain level?” “Well, I was at a seven and now I’m at a four.” That’s an improvement. When you move into a study like this that deals with animals, dogs for example, how does that work? How do you look at a dog in a situation like that and say, “This dog is in pain. We gave it CBD.” You can’t turn to the dog and be like, “What’s your pain level?” And the dog goes, “Ruff. Now I’m at a three. Ruff.” You know? Or something.

Matthew Halpert:
You don’t speak dog?

Matt Baum:
Not real well. My dogs don’t listen to me, I’ll tell you that much. Maybe I’m doing it wrong. I don’t know.

Matthew Halpert:
So, sure. Up to this point, this had been research in the lab in Petri dishes or test tubes, however you want to picture it. And right, this is a situation that plagues science. A lot of stuff can look great in the lab but does it actually hold up in an intact, biological system? We’re not talking about rodents that may all be genetically identical. We’re talking about genetically disperse subject such as humans or dogs in this case, that are also out bred. They’re not all genetically … They’re not clones of each other.

Matt Baum:
Not by any means, yeah.

Matthew Halpert:
No. So this came about largely with a collaboration with Medterra and so this is where they also put some weight and the bottom, basic question was, “all right. CBD reduces inflammation. So what?” I mean, that’s great and all but is it actually going to help people or, “Hey, we have a pet product. Is it helping dogs or not? Are we just following a fad or is there actual science here?” And while there is absolutely impetus to push CBD through the human clinical trial process, and I can drop a teaser that absolutely Medterra is looking into and will do that and that is upcoming.

Matt Baum:
That’s awesome.

Matthew Halpert:
That is a process. You still have to go … It’s not going to happen overnight. We have to integrate with the FDA. We have to integrate with the institution. It takes a bit of work. And it’s a little bit tricky sometimes to go from the lab and mouse work all the way to humans. Because sometimes maybe the FDA feels, “You don’t have a ton of justification here to do this or that.” So sometimes a middle ground is what occurred here with our K-9 friends. Because they are far more representative of a human population than maybe mice or cells in a dish would be.

Matt Baum:
Just because they’re all so different? Is that because different sizes, different-

Matthew Halpert:
I would go, I mean, dogs are easily more evolved, for example, than mice.

Matt Baum:
Oh, okay. Gotcha.

Matthew Halpert:
Their systems are a little more representative of ours. They’re genetically disperse, as we are. They live in the environment. They don’t live in an animal facility or in a cage. They live out and about.

Matt Baum:
They’re exposed to a lot of the same stuff we are. Absolutely.

Matthew Halpert:
And not only that but dogs, more than I would have thought, suffer from osteoarthritis. It is estimated between, and this is going to surprise you, but between 20% and 90% of dogs, depending on breed, will suffer from osteoarthritis at some point in their life.

Matt Baum:
Wow.

Matthew Halpert:
It is very prevalent.

Matt Baum:
I can say, speaking from experience, I had two pugs, both of which had serious arthritis. One is 13 and she has a nerve disorder and she has lost her back legs. But before that nerve went bad, she was in a lot of pain. Turns out it was arthritis.

Matthew Halpert:
Mm-hmm (affirmative). Which often leads to some poor options. There’s actually a need here to maybe have something that could work. Right. So at this point, we’ve got a collaborative effort going between myself at Baylor and the Medterra and their group and their board and then Sunset Animal Hospital who sees tons of arthritic dogs and would love to have something to offer them. And like you said before, you can’t just give one dog some CBD and say, “How do you feel?” That’s not a study. And so in designing the study, what everyone came to a decision on, I’ll say off the bat, there are more invasive and more expensive things that could have been done in this study but in a catch-22, the vets and the regulatory process was not going to approve all of those very invasive or very expensive things until there was a publication that even suggested real justification.

Matt Baum:
Of course. That makes perfect sense. The vet’s like, “Hey, by the way, I’d like to try this experimental thing on your dog. Baylor thinks it might be a good idea.” And they give it to the dog and the dog dies. That’s a really bad look. I get that.

Conducting the ‘Pain’ study of osteoarthritis & CBD in older dogs

Matthew Halpert:
Right. So you got to start baby steps, baby steps. And again, all done between oversight with Medterra and Sunset and so the study that came about was what I would consider an appropriately controlled pilot study. And so I always refer to it as a placebo control double blinded study. What that means is that the double blind means no one in the study knew which group they were in. What they were enrolled. That includes the vet, who did the enrolling, and that includes the enrolling who also did not know which group they were in and obviously if you want to, the dogs also don’t know what they’re taking.

Matt Baum:
The dogs weren’t in on it. They didn’t tell them.

Matthew Halpert:
Kind of triple blind. So no one knows if you’re in the highest dose group or maybe you’re in the placebo group where you’re not actually going to give your dog anything. And so this helps reduce bias. Answer honestly because you’re not really skewed. If you know you’re in the highest group of CBD or something, you may be subconsciously skewed to see benefits where there may not be.

Matt Baum:
I do feel better. And maybe you were just having a good day.

Matthew Halpert:
If you knew you were in the placebo group, you’d go the other way. “I know I’m not getting anything.” So we wanted to keep everyone blinded. And then the collation of it was all done after the fact when the study was done. All right. Let’s see what the data says. And the groups included a placebo group, a low dose of CBD, a higher dose of CBD, and then the low dose of CBD in a, let’s call it a Trojan horse, scientific technology that improves bioavailability.

Matt Baum:
Oh, okay. Gotcha.

Matthew Halpert:
It won’t change the biology but you will absorb it better than if you didn’t.

Matt Baum:
Than if you just gave it to them. Yeah.

Matthew Halpert:
Because CBD, as you may or may not know, no super soluble, not very bioavailable. When you take CBD, you’re probably only actually benefiting from 2% to 20% of it, while the rest of it is either excreted or metabolized by the liver. By putting it in a certain hijack, a certain lipid packaging, that absorption goes much, much higher. Between 10 to 20 fold higher.

Matt Baum:
Wow.

Matthew Halpert:
So you get a lot more benefit.

Matt Baum:
Can I ask what that was? What was the lipid mixture that they used in that?

Matthew Halpert:
I don’t know that I’m allowed to full answer you. That’s somewhat proprietary to Medterra’s efforts.

Matt Baum:
It’s probably not the coconut oil that everybody is using it in.

Matthew Halpert:
No.

Matt Baum:
I didn’t think so.

Matthew Halpert:
No coconut. But I can tell you, it’s something that Medterra is going to be offering post haste. That’s all in production, development right now to be offered because it’s going to be … get your monies worth, right? I mean, take the stuff that your body is going to use.

Matt Baum:
That’s going to change the business. Certainly going to change the business.

Matthew Halpert:
Yep. And so to this story, we had those four groups and the dogs were to consume their product, CBD or placebo or whatever dose orally for 30 days. Just squirt on their food, which again, is not going to be the most, not the ideal situation because I’ve seen dogs eat, it’s a little messy. But 30 days, which is very quick, and I am very up front about having gone on record and telling everyone, for starters I can’t manipulate the data. The data will be the data. You have to be ready for that. It may not work. Second of all, guys, it’s a 30 day study. That’s very quick, clinically speaking, for anything like a chronic condition.

Matt Baum:
You can only look at what happened in those 30 days and look at that data and say, “This is what we have.” We can’t go in saying, “We think it’s going to be this.” Or, “We know it’s this. How do we get there?”

Matthew Halpert:
No.

Matt Baum:
That’s not how it works.

Matthew Halpert:
You get the data and you also have to be careful with extrapolations. “Oh, something is safe for 30 days, it must be safe if you take it every day for two years.” No. That’s not what we studied, so I can’t say that. Here’s what I can say. Within the paper, the characteristics of the dog, we had a really good mix of male and female, we had a really good mix of breed. They all weighed about the same. They were all around give or take 80 pounds. So pretty big dogs. And they were all around, I’d have to check, 10 or 11 years old. This is representative of the population that is dealing with osteoarthritis.

Matt Baum:
That’s when arthritis shows up. Senior dogs.

Matthew Halpert:
Before and after scoring and then two week follow up scoring is how it was done. And the scoring was carried out by the veterinarian who knows how to appropriately analyze dogs for their arthritis and the have a numerical scoring system basically. And they could also do … What was also done was the blood work. Your typically CBC and chemistry to check for, “Are we doing anything to the liver? Are we seeing liver issues? Are we seeing kidney issues? Are we seeing any red flags?” This would all fall under the safety profile of the study. Is this safe? Does it look like it’s being well tolerated?

Matt Baum:
It doesn’t matter if the pain goes down if you have just inflated some other chemical that’s really bad for your kidneys or your liver or something.

Matthew Halpert:
Right. Not worth it if it shuts down your kidneys.

Matt Baum:
Exactly.

Matthew Halpert:
So we had to make sure that was analyzed and then there was before and after and follow up scoring by the owners who filled out what is termed the Helsinki Pain Scale Chronic Pain Index.

Matt Baum:
That’s the one where it’s like, “What is your pain level?” And you’re like, “Nine.” And they’re like, “Oh, you’re hurting.” Right?

Matthew Halpert:
Kind of. It’s a published study that the vets fill this in, it’s actually well accepted in scoring arthritis in dogs and it’s a questionnaire where the owners do score numerically from one to five or one to 10 but they’re different questions. They aren’t just what’s the pain? It’s, how is your dog able to … Is your dog willing to jump up onto something? Is your dog capable-

Matt Baum:
Mobility.

Matthew Halpert:
Mobility.

Matt Baum:
Is your dog shaking. Shaking is a good way to know a dog is in pain. Correct?

Seeing results from CBD and older dogs

Matthew Halpert:
Right. And of course, anyone who is listening can just Google, “Helsinki Pain Scale” and they can see the questions. It’s freely available online but it’s just nothing too invasive, but it’s a way to get some direction. Do the owners of these dogs, do they perceive there to be any benefit after 30 days of CBD use? Does your dog seem to be in less pain? Do they have better mobility? Based on the ways you would score a dog. Again, is where the veterinarians came in and explained all that. And of course, every owner filled out informed concent. This is all by the books and on the up and up and I was surprised to see the difference I saw after 30 days. It was much greater than I would have thought. And so-

Matt Baum:
Really?

Matthew Halpert:
Yes. And so in the placebo group and the low dose group, again, the owners and vet don’t know that those are the group when they’re doing the scoring. They were pretty consistent with each other in their scoring of, “We don’t really see a difference.” And you can see that in the, I think it’s figure six of the paper with the pie charts. But they did not see much difference. So if you just want to boil it down to better, worse, or no change, a bunch of no change. In both groups, in those 10 dogs. And then you’ve got the other two groups where it’s a little bit higher CBD or a better absorbed CBD, almost the exact opposite. 80%, 90% of the dogs in the different categories were definitely showing some level of benefit.

Matt Baum:
Wow.

Matthew Halpert:
And when you dive deeper into some of the scoring, there was an average of, again, I’d have to double check. 40% to 50% improvement in what I would call arthritic symptoms.

Matt Baum:
That’s amazing.

Matthew Halpert:
So these dogs, I agree, I’m quite frankly shocked.

Matt Baum:
That’s a crazy number. Normally if you looked at a study like that and you were like, “Wow. 20% of them did better. That’s a high number.” You know?

Matthew Halpert:
But some of the scores, again, it’s a little bit like golf where a lower score is better and so some of the dogs started at a very high score, I’ll just make up a number, 50. And then after 30 days it was down to 25. Well, that, again-

Matt Baum:
That’s incredible.

Matthew Halpert:
That’s pretty beyond the placebo effect which was very minimal in this study. I mean, it’s not just you scored things a little better. What you’re saying, what they were all basically saying is, “Yes, my dog is doing significantly better in a lot of areas.” And there were a lot of notes, “My dog seems much happier, more playful.” Things that I can’t include in the scientific paper because that’s not objective. I can’t put that in. I was like, “That’s really good to know.” And even arguably more impressive to me was at the 30 day mark, everyone was ordered to stop taking their product and then score again two weeks later. And in the groups that were getting the more efficacious amounts of CBD, they were still showing a statistically significant improvement, even two weeks later.

Matt Baum:
Wow.

Matthew Halpert:
Which means to me, as a scientist, that the CBD was not merely doing what a lot of pain relievers do.

Matt Baum:
Like masking.

Matthew Halpert:
Mask, right. It wasn’t just, “Oh, we masked the pain temporarily.” Because if that’s the case, then once you get rid of that, basically the pain is … the problem is still there. In this case, what it looks like is the CBD was in fact, over 30 days, genuinely reducing the inflammatory components and allowing for what I would call a more genuine foundational improvement. I mean, the pain was less because there was less issue.

Next steps for research into CBD & inflammation

Matt Baum:
There was less inflammation. Yeah. Let me ask the difference, what was the difference between the high dosage CBD and the low dosage with that agent that was helping distribute it?

Matthew Halpert:
Very close. They were not statistically different from each other.

Matt Baum:
Really? So basically whatever this thing Medterra is working on, is going to allow for lower dosages of CBD to be way more effective.

Matthew Halpert:
Correct. It’s going to be much safer to take because it’s not only going to be absorbed better, you’re going to actually avoid first pass metabolism by liver. So because it doesn’t go through the normal oral pathway, I mean, you still take it orally, but it basically sneaks out of the stomach and the intestines into your blood without going through the liver and without being metabolized. And if you’re avoiding the liver, you’re avoiding a lot of potential drug, drug interactions or issues with alcohol or anything else that affects the liver, which is basically everything. So this is going to be a very beneficial, a much safer and more efficacious product. Through a number of different studies, we’ve already shown it’s improved abilities.

Matt Baum:
That’s fantastic news, by the way.

Matthew Halpert:
I think for the CBD industry, we’re excited by that.

Matt Baum:
Yeah. What’s the next step here? Next to we do a two year study with dogs next? Or where do you go from here?

Matthew Halpert:
That’s a good question. We can go a couple of places from here. Obviously with this publication in tow, we absolutely I think have the justification to do a secondary K-9 trial if we want to do some more invasive things. Maybe we do look at the synovial fluid. Maybe we do some imaging. But before I do any of that, what I’ve actually done is I’ve gotten in contact with the FDA, the CBM department of the FDA. A lot of people don’t know but the FDA also regulates the animal space. And so I’ve been talking with them about working together on, how do we get this product … How does Medterra push this product through to be FDA approved in the K-9 space?

Matt Baum:
That’s the next huge thing.

Matthew Halpert:
What do you think we need to see? And they were pretty clear about, “Hold on, there’s a chance you might already have enough. We’re not sure.”

Matt Baum:
Oh, wow.

Matthew Halpert:
“Don’t do anything else until we look at everything you’ve got.” So I’m at a bit of a holding pattern in the K-9 space until the FDA weighs in and tells me either yes, we already have enough to be approved, and then we have a lot more potential of things we can do in studies. We have a much wider berth.

Matt Baum:
That sounds like good news to me though. Really.

Matthew Halpert:
Or they’ll say, there’s not quite enough data yet. It’s very promising. Here’s what we suggest. Here’s how we would recommend moving forward to achieve that. And so that might be a longer study. This is only a one month study. They may say, “We’d like to see this after six months.” And I would say, “Okay, now we know what our next study needs to revolve around. It needs to be a six month study where we determine safety and efficacy.” So I feel confident in saying there will be other K-9 studies but that has not been mapped out yet. And will almost certainly involve FDA input. The other place we go is into the human. So with all of the science that exists now, and now we have a really good in house example of this benefiting an actual arthritic population. I might not have said before but osteoarthritis in dogs is very similar to osteoarthritis in humans.

Matt Baum:
Yeah. You mentioned that.

Matthew Halpert:
They’re very similar conditions. So it’s not even a leap to say, “If this worked here, there is a reasonable shot it’s going to work here.” And I mentioned, it’s 35 million Americans a year are dealing with this.

Matt Baum:
I’m one of them.

Matthew Halpert:
I talked to our Rheumatologist who was like, please do this. There’s basically nothing. Basically these people just take ibuprofen or whatever.

Matt Baum:
You take drugs to mask the pain. That’s it.

Matthew Halpert:
Until eventually we’ve got to do a joint replacement. There’s really no solution. So great, we are in talks with rheumatologists in the Houston Med Center and writing up applications and everything is moving towards, let’s go for it. Let’s see if we see similar or even along the lines, results in humans. And that’s part of the reason I work with Medterra. Is they’ve always been very clear about science first. Forget the anecdotal. Forget the fads. And I’m going to put a little soap box down and say, over the years I’ve had the opportunity to myself analyze many different CBD products, including other attempts at this enhanced absorption vehicle, and I literally can look under the microscope sometimes and see that so and so is just full of it.

Matt Baum:
This is BS.

Matthew Halpert:
That’s not here. Oh, this is contaminated. What is that? Hair? I wouldn’t put that in my body. Because it’s not the most regulated space. Right? There is a fad mentality, a gold rush mentality, and people need to do their due diligence. Not all CBD is as clean as they would maybe expect. If they think that there’s some magical fairy that’s checking on all the companies to make sure they’re actually giving you CBD and not a bunch of other stuff. No they’re not.

Matt Baum:
That’s something we push heavily here at Ministry of Hemp and I’ve felt a lot of pushback from some people and I get it. We’re behind this. This is awesome. And it looks like the sky is the limit but we have to do the science right and we have to make sure the people are getting the right product and what’s actually in that bottle is what they’re saying it is. And it’s so easy to just cheer lead and go, “No, we got it. We did it. It’s curing everything.” It’s not the case and we have to do it the right way. It’s guys like you that I don’t get to talk to very often that are doing the hard science and I appreciate the hell out of it. Speaking as a skeptic myself, it’s so nice to hear, “Hey, here’s a study. We went into it not knowing what was going to happen. It had really good results.” Not showing up to the interview and going, “We all know it’s great. We all know it’s the best. And it’s going to cure everything and here’s how we proved it.” No. Please, don’t do that.

Matthew Halpert:
CBD is not the first fad. There have been fads like this before.

Matt Baum:
It’s not the 50,000th fad. You know?

Matthew Halpert:
And the future of it, I fully believe comes down to how science moves it forward. Either there’s a lot of scientific study, appropriate regulation, and evidence in legitimate clinical trials that people can point to and hang their hat on and it becomes, “Yes, CBD has been studied. It’s a controlled process. A controlled industry.” Or none of that is going to happen, or not enough of that is going to happen. And whatever does happen will be dwarfed by the magnitude of the, “Well, it helped my grandma do this.” Stories that people run with. And after a couple years, people sort of get tired of stuff like that. And they say, “Oh, yeah. I remember. I remember [inaudible 00:41:55] was curing everything. What happened to that? Can you get that at the store?”

Matt Baum:
I remember hydroxychloroquine. Right? Yeah.

Matthew Halpert:
Either there’s science and study or there’s not. But that will determine, if you want to fast forward a couple of years, that will determine how big and strong the CBD industry is. Especially in context of potential future legalization of marijuana as a whole. And so that’s going to be something that people are going to have to grapple with. That CBD and marijuana are not the same thing. And I’m sure you guys are all over that.

Matt Baum:
Oh, we know all about it. Yeah. Spend a lot of time trying to enforce that. Dr. Halpert, I want to thank you very much for coming on the show.

Matthew Halpert:
Thank you for having me.

Matt Baum:
This was fantastic. It was a great talk and you really boiled it down well. I barely had to jump in and be like, “Whoa, what’s that word mean?” And I can’t tell you how much I appreciate that.

Final thoughts from Matt

Matt Baum:
Huge thank for Dr. Halpert for coming on the show and it’s just so refreshing to talk to somebody from obviously such a high level of learning and scientific background that can boil something huge like this down to a level we can all understand and really there’s a lot of information in this interview that’s very exciting about the future and new frontiers for CBD. As always, you’ll be able to find links to Dr. Halpert’s bio, Medterra, and the study we discussed, all in the notes for this episode.

Matt Baum:
That’s about it for this episode. I just want to thank everybody that has been downloading and supporting, especially everybody that has gone to our Patreon page that’s Patreon/MinistryofHemp.com and become a Ministry of Hemp insider. Any amount that you donate not only helps us spread the good word of hemp, but it gets you early access to articles, all kinds of extras like podcast extras and bonus articles and information that you can’t find on the site. Like I said though, more importantly, it really helps us to keep doing what we’re doing and if you want to spread the good word of hemp and hemp education, there’s no better way to do it. Speaking of MinistryofHemp.com, we have a new review up for Winged Relaxation CBD gummies. They’re stress relief gummies but unlike a lot of stress relief CBD products, these won’t make you sleepy. And like I mentioned at the beginning of this show, we’ve got a fantastic article about five scams to watch for in the CBD world. I cannot stress how important it is that you go check that one out.

Matt Baum:
If you need more Ministry of Hemp in your life, you can follow us on all your favorite social media platforms @MinistryofHemp or /MinistryofHemp. We are always posting great stuff. At the Ministry of Hemp, we believe that an accessible world is a better world for everybody so you can find a full written transcript of this episode in the show notes as well. Now, usually I end the show the same way every time but it’s almost time to go back to school and I know a lot of people are being forced to go there. Whether you’re a teacher or a student. So I’m going to add to my usual sign off and I just want to say, be careful, wash your hands, wear a mask, take care of yourself, take care of others, and make good decisions, will you? This is Matt Baum with the Ministry of Hemp podcast, signing off.

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What is CBG? An Introduction to Cannabigerol (CBG) https://ministryofhemp.com/cbg-cannabigerol/ https://ministryofhemp.com/cbg-cannabigerol/#respond Thu, 02 Sep 2021 19:36:00 +0000 http://ministryofhemp.com/?p=62580 CBG or cannabigerol, is a natural compound found in hemp and cannabis. CBG may ease inflammation, promote bladder health and regulate mood.

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Cannabigerol, or CBG is one of more than 120 cannabinoids found in the hemp (cannabis) plant. It is showing great promise for treating a variety of ailments. 

In today’s article we’re going to be looking at the newest cannabinoid to rock the health and wellness industry since CBD made its splash a few years back. 

What’s interesting about CBG is that it’s sort of an enigmatic cannabinoid. Cannabis plants contain only trace amounts, yet it’s considered the “mother of all cannabinoids.” And, because it’s found in such small amounts, it makes it tough to study and research. 

“You have to be able to get enough to be able to test it and study it.”

With that said, we’re going to share what we do know about this amazing cannabinoid, so you can determine if it’s right for you. 

Table of contents

The ‘mother of all cannabinoids’

Before we jump into what all the fuss is about, it’s important to first give an overview of the science behind this cannabinoid, and why it’s considered the “mother” of all other cannabinoids. 

You see, cannabinoids start out in an acidic form. Before CBD becomes CBD, it starts out as Cannabidiolic acid (CBDA) and through heat or sunlight the acid burns off and you’re left with CBD. The same is true for THC and other cannabinoids; CBG is the precursor for this.

Cannabigerol (CBG) starts out as Cannabigerolic acid and morphs into other acid based cannabinoids, which in turn through heat and sunlight form into their various non-acid cannabinoids, such as CBD, THC, etc. 

Want a quick introduction to CBG? This video will get you started. Our video producer Desiree explains the basics of CBG, including comparing it with CBD, the better known compound made from hemp.

Thanks to our friends at Social CBD for sponsoring this video introduction to CBG!

We explain CBG in a lot more detail in the article below.

Photo: A diagram of the CBG molecule set against a backdrop of hemp leaves.
CBG, which stands for cannabigerol, is a potent natural compound found in hemp that can offer unique benefits compared to CBD, its better known cousin.

What is CBG oil?

So what exactly is CBG? Like CBD, CBG is a non-psychoactive cannabinoid — it won’t make you “feel high.” It’s most abundant in high-CBD hemp plants. High CBG strains also typically contain low levels of THC — the most common cannabinoid that is psychoactive. 

CBG works directly on receptors in our brain and nervous system, including CB1 and CB2 receptors, 5-HT1A and alpha-2 receptors, along with the TRPV1 and 2 receptors, and some other cannabinoid receptors. That sounds complex, so just know that brain receptors affect our senses, thoughts, mood, and even our central nervous system. 

CBG may even lessen the effects of paranoia sometimes caused by THC.

Possible benefits of CBG

Although medical studies are just getting underway, this compound shows great promise in aiding or treating a number of ailments.

We examined a number of published articles and research studies. We found healthline.com had the most thorough list of the medicinal benefits of CBG. Below is a summary of our research:

Of course, initial research is just that: an indication that this substance requires closer study. Just because something shows promise in the lab, or on rats, does not mean it will always help people in the real world.

One of the problems with studying CBG is the price – It’s expensive. 

Why is CBG so Expensive?

Like most things, the price of CBG comes down to supply and demand.  When the popularity of CBD really first hit the marketplace, the price was also high due to a lack of supply versus demand.

“You have to be able to get enough to be able to test it and study it.”

Perry Solomon, M.D., medical cannabis expert

However, CBG is a little different. As we touched on earlier, most hemp plants only contain trace amounts of CBG. In fact, a high-CBD hemp strain might contain as much as 20% CBD and only 1% of CBG. That means it takes huge amounts of biomass (hemp plant material) to a tiny amount of extract. Obviously, this increases the price.

According to Kent Vrana Ph.D., chair of the department of pharmacology at Penn State College of Medicine, that’s because cannabigerol doesn’t stick around for long.

In an article published on MSN.com chair of the department of pharmacology, Kent Vrana Ph.D., says it best “The plant (cannabis) generally doesn’t store it or accumulate CBG because it all gets converted to THC, CBD, and another compound,” Vrana told MSN.com.

There is an opportunity cost that comes down to two choices:

  1. Capture CBG before it synthesizes into the other cannabinoids (early harvest)
  2. Wait to harvest and get only trace amounts of CBG at full harvest.

No matter which choice is made, something else must give. If you capture CBG before it synthesizes, you aren’t able to harness the other cannabinoids. If you wait until a full harvest, you get only trace amounts of cannabigerol. 

According to Vrana, “plant biologists are now creating strains to increase the amount of CBG.”

Hopefully, prices will come down at some point. 

Interactions with medications

We still need to learn more about how CBG interacts with other medications.

Presently, there are no known interactions when combining CBG with medications. That could change as CBG sees more research and widespread usage. As always, it’s best to check with your doctor before taking CBG or any other cannabinoid

Users do need to need to be aware when taking medications that come with a grapefruit warning. We know that CBD can bind to the same enzymes that grapefruit does, specifically CYP450 enzymes. That could theoretically cause the body to take longer to process the drug, increasing levels in the bloodstream. Right now, we’re still learning how this works with CBD, so we know even less about CBG.

The most common medication types with grapefruit warnings are:

  • Cholesterol medications
  • Blood pressure medications
  • Heart rhythm medications
  • Anti-infection medications
  • Mood medications
  • Blood thinners
  • Pain medications
  • Erectile dysfunction and prostate medications

Be sure to check with your doctor before combining any of these drugs with CBG or CBD.

CBG vs. CBD 

Besides the fact CBD and CBG are different cannabinoid compounds, there are more similarities than differences between the two.

Both CBD and CBG:

  • Are Non-Psychoactive (won’t alter your state of mind)
  • Can counter the effects of THC
  • Have medicinal properties
  • All natural
  • Anti-Inflammatory
  • Anti-Bacterial
  • Have neuroprotective properties
  • Can lower glaucoma-related pressure

Can these two cannabinoids be taken together? Absolutely! In fact, it’s encouraged. Certain cannabinoids are known to work well together. CBD and CBG are two that do.  

CBD regulates levels of the body’s natural cannabinoids, which bind to brain receptors. CBG works closely with those same receptors. So, in a sense by combining the two, you’re getting benefits from both sides, a synergistic approach. 

For more information about these two cannabinoids, check out our complete CBD vs. CBG comparison.

How to take CBG

There are multitudes of ways to dose CBG. In general, taking this compound will be similar to CBD.

Here are the most common ways to take CBG:

Take a tincture

Just like CBD, tinctures are the most common way to take CBG. CBG, along with other cannabinoids, are extracted from hemp plants. Then, they’re mixed with a carrier oil (like hemp seed oil or MCT oil) to make a tincture.

Photo: A white woman in a fluffy sweater takes a tincture from a dropper.
Most people take CBG in tincture form, but other products are becoming available.

Cannabinoids can easily be combined in tincture form, meaning some products may contain cannabigerol alone while many more combine CBG with CBD and other trace cannabinoids.

How to consume: Tincture drops should be applied under the tongue and held for 60-90 seconds before swallowing.

A white woman's hand ashes a pre-roll hemp joint into a handmade wooden ashtray, decorated with crystals.
CBG can be smoked in joint form just like other forms of smokeable hemp flower.

Smoking high CBG flower

Instead of undergoing the extraction process, it’s possible to simply smoke strains of hemp that are high in CBG. Smoking is one of the most rapid and efficient ways of absorbing cannabinoids. As long as it contains less than 0.3% THC, hemp flower is fully legal to possess and consume in most parts of the U.S.

How to consume: The method is the same as other smokable hemp or cannabis products. You can buy pre-rolled hemp “joints,” or hemp buds that can be broken up and rolled into joints or smoked in a pipe.

Other ways to take CBG

  • You may be able to obtain an isolate powder. Take the powder directly. Just like CBD isolate powder, cannabigerol isolate can be taken directly under the tongue, sprinkled over food, etc. It is fat-soluble so it will dissolve nicely in liquids with a high fat content. 
  • Topically in skin-care creams. Since this compound has anti-bacterial and anti-fungal properties, it makes perfect sense to incorporate it into skin care products. There are companies working on CBG infused skin care products, so stay tuned.
  • We can expect to see gummies and other innovative products as the market expands.

More than just hype

We sincerely hope this article sheds some light on the newest cannabinoid to hit the marketing since CBD. Just like the splash CBD made a few years back, there is a great deal of hype surrounding CBG and its potential uses and benefits.  

While CBG might be the “buzzworthy” supplement at the moment, early research is promising. However, as with all cannabinoids, the market is still in its infancy. Much more research needs to be done.

In the meantime, try CBG out for yourself, experiment to find your perfect dosage, combine it with CBD and see if it works for you. 

Kit O’Connell contributed to this guide.

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Hemp In Space: Researchers Send Hemp Plants To International Space Station https://ministryofhemp.com/hemp-in-space/ https://ministryofhemp.com/hemp-in-space/#respond Fri, 12 Oct 2018 18:48:35 +0000 http://ministryofhemp.com/?p=54382 Hemp in space sounds like a science fiction dream. Earth researchers will soon begin growing hemp in space on a tiny laboratory aboard the International Space Station, created by Space Tango in partnership with Anavii Market.

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Hemp in space sounds like a science fiction dream. It will soon to be an exciting new reality thanks to a partnership of terrestrial firms hoping to learn about the effects of microgravity on the crop.

Space Tango, a start-up business from the heart of Kentucky seeks to harvest hemp in space. Co-founder and chairman, Kris Kimel, wants to lean about how the biology and quality of the crop will develop without the influence of gravity. The goal is to see if the medicinal value of cannabinoids prospers on this new frontier and to offer unique CBD products to the public.

Anavii Market is partnering with Space Tango on their journey into this new frontier. Anavii Market is an online CBD marketplace that seeks to improve quality reliability in the industry. Their goal is to provide a trusted source of CBD to the public.

A photo of the International Space Station in orbit over earth, Space Tango and Anavii Market will soon begin experimenting with the immense potential of growing hemp in space.
Space Tango and Anavii Market will soon begin experimenting with the immense potential of growing hemp in space. (Photo: NASA)

We caught up with Kimel to learn about Space Tango’s hemp project.

He told us, “We’re primarily interested in looking at how biomedical … systems operate and change when removed from the gravity well of earth.”

WHAT WE KNOW ABOUT GROWING HEMP IN SPACE

Prior to Space Tango, Kimel was the founder and president of the Kentucky Science and Technology Corporation (KSTC), “which is where this notion of looking into space and microgravity kind of germinated.” As his interest grew, he left the company and moved over to Space Tango full time.

After nearly a decade of research on this new frontier, Kimel tells us there’s still so little they know and so much to learn when it comes to how plants develop in a gravity stress-free environment. Since hemp has had such little research within the last century and only recently has had its doors opened to scientists, Space Tango remains optimistic in breaking through new discoveries.

Kimel and his team are aware that principle biological systems (i.e. cells, organisms) become scrambled grown without gravity. In turn, this “opens up new pathways, new understandings, of those systems that you’d never see on earth.” Prior to their experiments with hemp, they’ve developed medical implants which can only be manufactured in space.

HEMP IN SPACE: HOW IT ALL WORKS

Permanently installed on the International Space Station are two research and development laboratories for the Space Tango team. Within each of those labs are 21 component parts of operations known as CubeLabs. The purpose of these modules is to reduce the amount of hands-on interaction required to grow organisms in space. They’re about the size of a “Kleenex tissue box and fully equipped with microtechnology.”

CubeLabs function to:

  • Operate independently.
  • Supply a responsive payload.
  • Process data and images to earth in real-time.
  • Reduce application development life-cycle.
  • Decrease astronaut interplay.

Space Tango's module on the International Space Station features multiple "CubeLabs," modular research labs each the size of a box of tissues. The firm will soon be growing hemp in space in one of these labs.
Space Tango’s module on the International Space Station features multiple “CubeLabs,” modular research labs each the size of a box of tissues. The firm will soon be growing hemp in space in one of these labs. (Photo: NASA)

The purpose of these CubeLabs is to find medical solutions which can be applied back here on earth. This is also Space Tango’s primary interest in cultivating hemp. “Our science team has looked at recent developments of CBD and we think an enhance in cannabis and CBD holds great potential for treatment of serious conditions such as epilepsy or migraine headaches.”

Furthermore, due to cannabis’s entanglement in legal issues, new research is constantly being developed. Kris believes him and his team have the ability to discover aspects of CBD and marijuana which aren’t currently there. He tells us, “What we do know in combination with microgravity holds very great potential.”

THE FUTURE OF HEMP IN SPACE

If these experiments go as planned, Space Tango hopes to offer CBD products to both consumers and the medical industry. The first experiments with hemp in space are scheduled to begin in either January or February of 2019. Due to regulations and policies with both the state and NASA, there are some legal actions Space Tango still needs to take before allowing hemp to enter this new frontier. However, Kimel informs us that Space Tango is committed to making sure they go about the experiments the right way.

So, how do these experiments work?

“Obviously, things are more difficult and complicated in space,” Kimel tells us. “Once the technology is designed, we install it into our labs and, from there, it takes about four to six weeks and then they’re brought back to the lab for analysis.”

Through these analyses, Space Tango believes they can find treatment for certain diseases which you couldn’t find here on earth. Kimel claims, “you get a better resolution with certain kinds of drugs in space.”

“Our ultimate goal is to have a transformational benefit of life on earth,” he concluded.

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Mitch McConnell Wants To Legalize Hemp With New Farming Bill https://ministryofhemp.com/mitch-mcconnell-hemp/ https://ministryofhemp.com/mitch-mcconnell-hemp/#respond Thu, 29 Mar 2018 17:32:19 +0000 http://ministryofhemp.com/?p=53967 Sen. Mitch McConnell, the Senate Majority Leader, wants to fully legalize hemp. Though the text of McConnell's bill is not yet available, the goal is to remove agricultural hemp from the Controlled Substances Act, preventing government agencies like the Drug Enforcement Administration from interfering with hemp growers or vendors of hemp products like CBD oil.

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Sen. Mitch McConnell, one of America’s most powerful politicians, wants to fully legalize hemp.

McConnell, the Senate Majority Leader, announced the proposed hemp legalization legislation at a press conference on Monday, March 26.

“Hemp has played a foundational role in Kentucky’s agricultural heritage, and I believe that it can be an important part of our future.” – Senator Mitch McConnell

Though the text of the bill is not yet available, the goal is to remove agricultural hemp from the Controlled Substances Act, preventing government agencies like the Drug Enforcement Administration from interfering with hemp growers or vendors of hemp products like CBD oil. The “Hemp Farming Act of 2018,” which is expected to be introduced in early April, could complete the process of re-legalizing hemp which began under the 2014 Farm Bill.

“Basically, it tells everyone in the world that the U.S. is open for business with hemp,” said Brian Furnish, a hemp grower from Kentucky and president of theUS Hemp Roundtable.

Mitch McConnell hemp bill would remove industrial hemp from the Controlled Substances Act
A U.S. Senate Committee meeting room. Sen. Mitch McConnell announced the “Hemp Farming Act of 2018, which would remove industrial hemp from the Controlled Substances Act and make it an agricultural commodity.

Furnish said that hemp would be treated like any other “agricultural commodity” under this new law, with each state’s agriculture department able to regulate growers as they see fit.

Furnish and the Roundtable have made passing a bill like this the major focus of their political lobbying. He and many other hemp advocates hope that McConnell’s “Hemp Farming Act of 2018” will succeed where previous efforts have failed.

“I have been pushing for two years for this day,” Furnish told us on Monday.

NEW HEMP LEGISLATION NEEDED TO FREE HEMP FROM DEA INTERFERENCE

“The devil’s always in the details, right?” said Eric Steenstra, president of Vote Hemp when we asked him about the announcement. “They haven’t released the language of the bill yet and, as I understand it, there’s still some conversations going on about little details.”

He’s hopeful though. “From everything I’ve heard, it sounds like it’s going to be a good bill.”

While it’s hard to judge the potential impact of legislation before it’s even introduced, the need for a legal change is clear. An amendment to the 2014 Farm Bill legalized hemp for research purposes, allowing each state to set the terms of that research program. Hemp advocates argue that the farm bill is broadly written enough to include market research, including sales of hemp products like CBD oil, the popular supplement used to alleviate symptoms of chronic pain, epilepsy, and a host of other conditions.

But government agencies like the DEA and the Food and Drug Administration have attacked the legality of CBD oil, primarily by arguing it remains illegal under the Controlled Substances Act. Despite the Farm Bill and legal recreational or medical programs in numerous states, the DEA argues that all forms of the cannabis plant remain illegal at the federal level. The CSA classifies cannabis and hemp as harmful drugs with no medical benefits or safe use, despite the mountain of evidence to the contrary. The result of the conflict has been lawsuits and sometimes police raids on vendors.

A hemp transplant ready to be planted. New legislation is needed to fully support the U.S. hemp industry. That’s where Sen. Mitch McConnell comes in.

Additionally, the 2014 Farm Bill is set to expire in 2019, and while it’s expected to be renewed sometime this year, it’s another sign that a permanent solution is needed.

That’s where Mitch McConnell and his Hemp Farming Act come in. According to Furnish, McConnell’s bill would completely remove hemp from the CSA. He said the bill is expected to include “hemp and all of hemp’s byproducts” including CBD oil, as long as all products and hemp crops remain under the 0.3 percent THC limit set under the Farm Bill.

MITCH MCCONNELL BELIEVES HEMP IS ‘AN IMPORTANT PART OF OUR FUTURE’

Hemp is supported enthusiastically by lawmakers from both parties. Mitch McConnell’s announcement of the Hemp Farming Act is evidence that even top Republicans want to see hemp growing from coast to coast.

“Hemp has played a foundational role in Kentucky’s agricultural heritage, and I believe that it can be an important part of our future,” Senator McConnell said in a press release.

These changing attitudes are a sign of the success of the research programs launched by the Farm Bill, and Kentucky is one of the leaders in the country’s budding new hemp industry. The state harvested 3,100 acres of hemp in 2017, according to Vote Hemp’s data, but Furnish says that’s just the beginning.

“I think in Kentucky we can go from 5,000 production acres in 2017 to 100,000 by the end of the next 7 or 8 years,” he said.

Ministry of Hemp will continue to monitor this story as the full text of Sen. Mitch McConnell’s “Hemp Farming Act” is released.

 

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The Right & Wrong Way To Legalize Hemp In Kansas https://ministryofhemp.com/hemp-in-kansas/ https://ministryofhemp.com/hemp-in-kansas/#respond Tue, 06 Feb 2018 14:00:07 +0000 http://ministryofhemp.com/?p=34825 It is hard to understand how Kansas, a land of beautiful prairies and the nation’s third highest number of agricultural acreage, is one of the last states to end prohibition of industrial hemp. But will farmers be shut out by the new legislation?

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It is hard to understand how Kansas, a land of beautiful prairies and the nation’s third highest number of agricultural acreage, is one of the last states to end prohibition of industrial hemp.

Thirty-four states have now passed hemp legislation including New York state.

In fact, Governor Cuomo recently earmarked over $2.6 million for a hemp processing plant and seed certification program, and wants to make New York state a national leader in hemp production.

With China and Korea leading the world in hemp production, Russia now the world’s largest exporter of wheat and other nations increasing grain production, the U.S. is no longer the world’s only agricultural superpower. Hemp provides for over 50,000 products spanning across 10 different industries. My coalition, Kansans for Hemp, has conducted community forums across the state and continues to hear that farmers need the Kansas Senate Agriculture and Natural Resources Committee to allow hemp legalization bill HB 2182 to have a hearing, dropping any proposed legislation that leaves farmers out. Research was already conducted at Kansas State University during the 1970s, now it is up to Kansas lawmakers to not “research out the farmers” as some lawmakers have proposed.

WILL FARMERS GROW HEMP IN KANSAS? A TALE OF TWO HEMP BILLS

Given the low prices for wheat, corn and soybeans, Kansas farmers desperately need a more profitable alternative. Because of low prices, farmers have to increase yields per acre to break even or make a small profit. Increased supplies of grain put downward pressure on prices, and we have a vicious economic cycle that farmers cannot escape — unless they have the economic freedom to diversify commodities and grow a more profitable crop.

Hemp Field In Summer
A dense field of green bamboo-like industrial hemp stalks grows tall in the summer sunshine. Industrial hemp can be harvested for thousands of uses.

The people of America’s Heartland know good public policy is made through input from many stakeholders, so when introducing a new commodity offering as much opportunity as hemp does it makes sense why the number of those involved increases. In 2017, two hemp bills were introduced and as with most revenue-generating issues, there are now multiple influences attempting to guide the outcome.

One hemp bill (HB 2209) was introduced which only allows universities the ability to cultivate hemp for research purposes, it never had a hearing. The second bill (HB 2182) is closely modeled after laws in Tennessee and Kentucky. It was passed out of committee and passed the House floor by a vote of 103-18. The house bill was then sent to the Senate Ag committee, however the Chairman (Sen. Kerschen) chose not to deal with it because of how late it was in the session. The state lobbyist and Kansans for Hemp were told there would be a hearing in 2018.

The first day of 2018 session, Chairman Kerschen instead introduced a Senate version of HB 2209, titled SB 263. To be clear, both SB 263/HB 2209 are limited, watered down legislation that is in fact not in compliance with the 2014 Farm Bill, Sec 7606, the landmark federal legislation which re-legalized hemp in the U.S. HB 2209 also cuts out farmers completely as it leaves out crucial details of any licensing administration processes, and excludes other entities like technical and community colleges from doing research.

A source told us that there has been a pledge of money from the representative who introduced the House version, to help with the research (which seems unethical). Chairman Kerschen is ignoring HB 2182, including the 103 votes from the House, and held a two-day hearing on SB 263 which again is not what we have continuously heard that Kansas communities want or need.

KANSAS LAWMAKERS MUST STUDY OTHER STATES’ HEMP LAWS

Kansas needs to look no further than across the western border into Colorado to see there is room for all when it comes to this rapidly expanding industry.

Hemp Harvest
A farmer harvests hemp with a tractor under a cloudy sky. Legal hemp in Kansas must allow for growing by everyday farmers, not just academic institutions.

However, contrary to what some organizations claim additional, exclusive research is not necessary under the 2014 Farm Bill. Pilot programs which are open to farmers (like HB 2182 establishes) are approved under a state’s department of agriculture, and do not require oversight from any other agency, including law enforcement.

By contrast, bills like SB 263 completely take farmers out of the equation which will not only yield inaccurate or non-comprehensive research conclusions, but distrust will come from farmers who will continue to not be allowed to gain crucial experience necessary to understand best methods for propagating, cultivating, and harvesting industrial hemp.

Lawmakers could also look to the restrictive hemp laws in Virginia for an instructive example of what not to do. As reported in January by Marijuana Business Daily, laws in that state make it impossible to profit from hemp growing, and as a result interest in the crop has languished, with just 100 acres grown in 2017.

“We’re way behind the ball,” Virginia farmer Graham Redfern complained to Marijuana Business Daily’s Kristen Nichols.

LEGAL HEMP IN KANSAS OFFERS HOPE FOR FARMERS

With downward trends in markets, our rural and frontier communities need support now more than ever. Hemp is a perfect opportunity where they are willing to collaborate with the state and other entities on something that is new and exciting.

Research and production must be happening simultaneously, because how we move forward as contributing leaders is through both innovation and practical application. Kansans are known for dreaming big, but we cannot allow our own fears or the stories we tell ourselves guide decisions that negatively impact our children and grandchildren’s futures.

In 1863, Kansas was the number one producer in the nation of bushels per acre of industrial hemp. Now is the time to be courageous and give this legacy crop back to Kansas farmers, and help contribute to the nation’s largest developing industry. On February 1, 2018, SB 263 passed out of committee with amendments to the full Senate. It has yet to be determined if farmers will be included in a Kansas industrial hemp program.

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